Analysing the effectiveness of Just-A-Minute Optometry Clinical Pearls: a micro-learning tool in continuing optometry education.

CLINICAL RELEVANCE: Just-A-Minute Clinical Pearls as a microlearning concept may be beneficial in enhancing optometry and ophthalmology practice globally. BACKGROUND: Medical education often witnesses a gap in effectively translating the learnings into clinical practice, pointing to the complex and traditional teaching methods as hindrances. The present work studied the usefulness and acceptability of Just-A-Minute Optometry Clinical Pearls, a micro-learning tool, among optometrists and ophthalmologists. METHODS: Just-A-Minute Optometry clinical pearls were developed by the optometry team of LV Prasad Eye Institute and shared (via email) among optometrists and ophthalmologists on a daily basis between June 2021 to May 2022. In the middle of the project, the recipients were invited to participate in an online survey. The variables studied included frequency of checking clinical pearls, simplicity of their content, grasping speed, most used subspeciality pearls, knowledge gain and retention, practice applicability, overall learning experience, and the likelihood of recommending it to a friend. RESULTS: Among 150 respondents, 103 (68.7%) were ophthalmologists, and 46 (30.7%) were optometrists. The majority were from private (n = 64, 42.7%) and institutional (n = 48, 32%) practices, with 102 (68.4%) having more than five years and 21 (14%) having 2-5 years of experience. About 115 (77%) respondents checked clinical pearls every day, 147 (99%) found the format easy, and 131 (88%) could grasp the content within one minute. They felt that JAM-OCP 'always' enhanced clinical knowledge (n = 108, 72%) and clinical applicability (n = 82, 55%) and helped in knowledge retention (n = 123, 84%). The responses to the clinical application significantly varied (Chi-square tests) among subgroups of education qualification (p < 0.001) and practice types (p < 0.03). CONCLUSIONS: The Just-A-Minute Optometry Clinical Pearls were beneficial to optometrists and ophthalmologists in their practices. This, as a tele-education tool, supports continuing optometry education across the globe.

Disruptive behaviors, antisocial attitudes, and aggression in young offenders: Comparison of Adverse Childhood Experience (ACE) typologies.

BACKGROUND: Adverse Childhood Experiences (ACE) are associated with many deleterious outcomes in young offenders. There is a dearth of studies examining its effects on young offenders' antisocial attitudes, disruptive behaviors and aggression, risk factors for delinquency and reoffending. OBJECTIVE: This study examined ACE patterns and their association with the above factors in young offenders. PARTICIPANTS AND SETTING: 1130 youth offenders (964 males; Mage = 17.57 years), provided self-reports on ACEs, antisocial attitudes, disruptive behavior ratings and aggression. METHOD: Latent Class Analysis was performed on 12 self-reported ACEs, followed by Analyses of Covariance on each of the measures. RESULTS: Four classes - Low ACE, Indirect Victims, Abusive Environment, and Polyvictimized - were identified. Polyvictimized youths had the highest levels of conduct problems (M = 70.35, ps < .05) and proactive aggression (M = 0.45, ps < .05) but did not differ from youths in Abusive Environment in reactive aggression (M = 1.02, p = .69), oppositional problems (M = 65.15, p = .18), and antisocial attitudes (M = 26.95, p = .21). Indirect Victims had lower levels of conduct problems (M = 64.80, p < .05) and antisocial attitudes (M = 24.35, p < .05) than Polyvictimized youths but higher levels of these outcomes than the Low ACE group. CONCLUSIONS: Our findings showed that ACEs patterns vary in their effects on antisociality and disruptive behaviors. The novel finding was that childhood victimization does not have to be direct, as indirect victimization significantly impacted factors important to delinquency and reoffending.

Child maltreatment and protective assets in the development of internalising and externalising problems: A study of youth offenders.

INTRODUCTION: An emerging trend in child maltreatment research focuses on identifying protective assets that contribute to youth resilience. Extending the trend, this study examines not just whether but also how protective assets in various domains (e.g., the individual, family, and schools) are associated with internalising and externalising problems among youth offenders, which is a population that typically reports a high prevalence of child maltreatment experiences. METHODS: This study used the baseline data of 790 youth offenders (85% male) aged between 12 and 19 years old from the EPYC project, a national longitudinal study in Singapore. Structural equation modelling was conducted to test the direct effects and interactive effects of protective assets and child maltreatment on internalising and externalising problems. RESULTS: For direct effects, maltreated youth offenders reported higher levels of internalising and externalising problems than their non-maltreated counterparts. Higher levels of peer assets were directly related to lower levels of externalising, but not internalising problems. For interactive effects, overall protective assets, school/work assets and internal assets had significant buffering effects against physical/emotional abuse on externalising problems, whereas peer assets showed significant buffering effects against sexual abuse on internalising problems. CONCLUSION: An overall level of protective assets, as well as assets from specific domains (peer, school/work, and internal assets) could provide protective effects on problematic behaviours among youth offenders. Interventions seeking to address youth internalising and externalising problems should focus on reducing child maltreatment incidence and enhancing protective assets within these domains.

Relationship between Adverse Childhood Experiences and substance use in youth offenders in Singapore.

BACKGROUND: Adverse Childhood Experiences are associated with worse outcomes in delinquency and substance use. OBJECTIVE: Current research is overwhelmingly from Western perspectives, leaving a gap in non-Western, low crime-rate jurisdictions. Moreover, there exists a gap in characterizing the effect of ACE frequency on delinquency. We extend existing research by examining relationships between ACE and substance use in youth offenders in Singapore. PARTICIPANTS AND SETTING: The study included 790 youth offenders (669 males, Mage = 17.59 years) from a longitudinal study on youth offending. METHODS: Multiple regression was performed to examine relationships between self-reported ACEs and substance use. Latent Class Analysis was conducted to identify classes of substance use onset. The relationship between these classes and cumulative ACEs and ACE frequency were then tested using multiple regression. RESULTS: Youth offenders who consume alcohol (B = 0.66, p = .002) and illicit drugs (B = 0.38, p = .02) had more cumulative and more frequent ACEs than those who do not. Moreover, we found a positive relationship between ACEs and substance use frequency. Those who started taking substances in childhood had significantly more ACEs and had worse drug dependency problems than those who started later (t = 5.93, p < .0001). Additionally, there was a positive relationship between ACEs and drug use dependency (B = 0.11, p = .03). CONCLUSIONS: Our findings highlight the importance of ACEs as risk factors for substance use. This underscores the need for comprehensive screening and treatment of ACEs and substance use in the rehabilitative context.

Effectiveness of Functional Family Therapy in a Non-Western Context: Findings from a Randomized-Controlled Evaluation of Youth Offenders in Singapore.

This study is the first to evaluate Functional Family Therapy (FFT) in a non-Western culture. The effectiveness of FFT was examined in relation to three proximal outcomes relevant to youth offender rehabilitation: (i) mental well-being, (ii) family functioning, and (iii) probation completion. 120 youth probationers (Mage = 16.2, SD = 1.33) were randomly assigned to receive either standard probation services-Treatment-As-Usual (TAU; n = 57)-or FFT in addition to TAU (FFT; n = 63). Data on psychometric measures of mental well-being and family functioning were obtained at (i) preprogram, (ii) postprogram, and (iii) at the end of probation. Probation completion data were obtained from casefile records. Mean mental well-being scores of the FFT group improved from pre- to post-treatment, and gains were maintained at follow-up. However, there was a nonsignificant trend for the FFT group showing higher rates of reliable change and clinical recovery on the mental well-being scale. There were no group differences in family functioning scores over time. However, there was a significant trend for the FFT group showing higher rates of reliable change and clinical recovery on the family functioning scale. Probation completion rates were 88.9% and 70.2% for the FFT and TAU groups, respectively. Youth in the FFT group were significantly more likely to complete probation successfully. The results support FFT's effectiveness in Singaporean youth offenders. At a broader level, the study findings support the cross-cultural effectiveness of FFT in, and transportability to, a non-Western culture.

Este estudio es el primero en evaluar la Terapia Familiar Funcional (TFF) en una cultura no occidental. Se analizó la eficacia de la TFF en relación con tres resultados proximales relevantes para la rehabilitación de los delincuentes juveniles: (i) bienestar mental, (ii) funcionamiento familiar y (iii) término de la libertad condicional. Se distribuyeron aleatoriamente 120 jóvenes en libertad condicional (Edad Promedio = 16.2, Desviación Típica= 1.33) para recibir servicios de libertad condicional estándar-tratamiento habitual (TH; n = 57)-o TFF además del TH (TFF; n = 63). Se obtuvieron datos sobre las medidas psicométricas de bienestar mental y funcionamiento familiar en los siguientes momentos (i) antes del programa, (ii) después del programa y (iii) al final de la libertad condicional. Se obtuvieron datos del término de la libertad condicional de los expedientes judiciales. Los puntajes del bienestar mental promedio del grupo de TFF mejoraron desde antes a después del tratamiento, y se mantuvieron los avances en el seguimiento. Sin embargo, hubo una tendencia no significativa en el grupo de TFF que indicó índices más altos de cambio fiable y recuperación clínica en la escala de bienestar mental. No hubo diferencias entre los grupos en los puntajes de funcionamiento familiar en el transcurso del tiempo. Sin embargo, hubo una tendencia significativa en el grupo de TFF que indicó índices más altos de cambio fiable y recuperación clínica en la escala de funcionamiento familiar. Los índices de término de la libertad condicional fueron 88.9 % y 70.2 % en los grupos de TFF y de TH respectivamente. Los jóvenes del grupo de TFF fueron considerablemente más propensos a terminar la libertad condicional satisfactoriamente. Los resultados respaldan la eficacia de la TFF entre los delincuentes juveniles singapurenses. A nivel general, los resultados del estudio respaldan la eficacia intercultural de la TFF en una cultura no occidental y la transportabilidad hacia ella.

Thickness of Intraretinal Layers in Patients with Type 2 Diabetes Mellitus Depending on a Concomitant Diabetic Neuropathy: Results of a Cross-Sectional Study Using Deviation Maps for OCT Data Analysis.

Optical coherence tomography (OCT) supports the detection of thickness changes in intraretinal layers at an early stage of diabetes mellitus. However, the analysis of OCT data in cross-sectional studies is complex and time-consuming. We introduce an enhanced deviation map-based analysis (MA) and demonstrate its effectiveness in detecting early changes in intraretinal layer thickness in adults with type 2 diabetes mellitus (T2DM) compared to common early treatment diabetic retinopathy study (ETDRS) grid-based analysis (GA). To this end, we obtained OCT scans of unilateral eyes from 33 T2DM patients without diabetic retinopathy and 40 healthy controls. The patients were categorized according to concomitant diabetic peripheral neuropathy (DN). The results of MA and GA demonstrated statistically significant differences in retinal thickness between patients and controls. Thinning was most pronounced in total retinal thickness and the thickness of the inner retinal layers in areas of the inner macular ring, selectively extending into areas of the outer macular ring and foveal center. Patients with clinically proven DN showed the strongest thinning of the inner retinal layers. MA showed additional areas of thinning whereas GA tended to underestimate thickness changes, especially in areas with localized thinning. We conclude that MA enables a precise analysis of retinal thickness data and contributes to the understanding of localized changes in intraretinal layers in adults with T2DM.

Deviation Maps for Understanding Thickness Changes of Inner Retinal Layers in Children with Type 1 Diabetes Mellitus.

Purpose: To analyze the use of deviation maps (DevMs) to understand thickness changes of inner retinal layers in optical coherence tomography (OCT) data. To test a new visual analytics (VA) method with reduced complexity of OCT data analysis by comparing the layer thickness of children with type 1 diabetes mellitus (T1DM) to matched controls. Methods: OCT was performed on unilateral eyes of 26 children with T1DM without diabetic retinopathy and 29 healthy children to obtain macular volume scans. Subsequently, segmented inner retinal layers were analyzed using VA. Deviation maps were generated to readily visualize thickness differences between both groups and to investigate thickness changes of individual patients in relation to the control group. Results: In DevMs of the patient group, the total retina (TR) demonstrated localized, irregular areas of thinning (mean ± standard deviation) involving foveal center, inner macula, and inferior-nasal outer macula (-9.31 ± 1.73 µm; p < 0.05). Similarly, retinal nerve fiber layer showed continuous and localized areas of thinning in both inner and outer macula, extending nasally (-5.45 ± 4.31 µm; p < 0.05). In DevMs of individual patients, the TR and inner retinal layers revealed remarkable changes in thickness that were present between patients at both late and early stages of diabetes. Conclusion: The VA method simplifies the in-depth analysis of OCT volume data from different groups and is effective in detecting retinal thickness changes in children with diabetes. It can be easily adopted in a clinical set-up and intuitively used in complex multidisciplinary studies.

Corneal Subbasal Nerve Plexus Changes in Severe Diabetic Charcot Foot Deformity: A Pilot Study in Search for a DNOAP Biomarker.

INTRODUCTION: Diabetic neuroosteoarthropathy (DNOAP) early symptoms are unspecific, mimicking general infectious symptoms and rendering a diagnosis challenging. Consequently, unfavourable outcomes occur frequently, with recurrent foot ulceration, infectious complications, and eventually amputation. Corneal confocal microscopy (CCM) of the subbasal nerve plexus (SNP) is used to detect early peripheral neuropathy in diabetic patients without diabetic retinopathy. This pilot study was designed to determine if specific SNP changes manifest in severe DNOAP in comparison to a healthy control group. METHODS: This pilot study utilized a matched-pair analysis to investigate SNP changes by in vivo CCM for 26 patients (mean patient age 63.7 years, range 27 to 78) with severe DNOAP defined by condition after the need for reconstructive foot surgery (n = 13) and a healthy control group (n = 13). Corneal nerve fibre length (CNFL), nerve fibre density (CNFD), nerve branch density (CNBD), average weighted corneal nerve fibre thickness (CNFTh), nerve connecting points (CNCP), and average weighted corneal nerve fibre tortuosity (CNFTo) were assessed as well as the general clinical status, diabetic status, and ophthalmologic basic criteria. RESULTS: In vivo CCM revealed significantly reduced SNP parameters in the DNOAP group for CNFL (p = 0.010), CNFD (p = 0.037), CNBD (p = 0.049), and CNCP (p = 0.012) when compared to the healthy control group. Six patients (46%) of the DNOAP group suffered from diabetic retinopathy and none of the control group. CONCLUSIONS: This pilot study revealed a rarefication of SNP in all measured parameters in patients with severe DNOAP. We see a potential value of CCM providing a SNP-based biomarker for early stages of DNOAP prior to the development of any foot deformities that needs to be evaluated in further studies. This trial is registered with German Clinical Trials Register (DKRS) DRKS00007537.

Role of Bone Morphogenetic Protein 7 (BMP7) in the Modulation of Corneal Stromal and Epithelial Cell Functions.

In the cornea, healing of the wounded avascular surface is an intricate process comprising the involvement of epithelial, stromal and neuronal cell interactions. These interactions result to the release of various growth factors that play prominent roles during corneal wound healing response. Bone morphogenetic proteins (BMPs) are unique multi-functional potent growth factors of the transforming growth factor-beta (TGF-β) superfamily. Treatment of corneal epithelial cells with substance P and nerve growth factor resulted to an increase in the expression of BMP7 mRNA. Since BMP7 is known to modulate the process of corneal wound healing, in this present study, we investigated the influence of exogenous rhBMP7 on human corneal epithelial cell and stromal cell (SFs) function. To obtain a high-fidelity expression profiling of activated biomarkers and pathways, transcriptome-wide gene-level expression profiling of epithelial cells in the presence of BMP7 was performed. Gene ontology analysis shows BMP7 stimulation activated TGF-β signaling and cell cycle pathways, whereas biological processes related to cell cycle, microtubule and intermediate filament cytoskeleton organization were significantly impacted in corneal epithelial cells. Scratch wound healing assay showed increased motility and migration of BMP7 treated epithelial cells. BMP7 stimulation studies show activation of MAPK cascade proteins in epithelial cells and SFs. Similarly, a difference in the expression of claudin, Zink finger E-box-binding homeobox 1 was observed along with phosphorylation levels of cofilin in epithelial cells. Stimulation of SFs with BMP7 activated them with increased expression of α-smooth muscle actin. In addition, an elevated phosphorylation of epidermal growth factor receptor following BMP7 stimulation was also observed both in corneal epithelial cells and SFs. Based on our transcriptome analysis data on epithelial cells and the results obtained in SFs, we conclude that BMP7 contributes to epithelial-to-mesenchymal transition-like responses and plays a role equivalent to TGF-β in the course of corneal wound healing.

[Visual Analysis of Retinal OCT Data]. / Visuelle Analyse von retinalen OCT-Daten.

Optical coherence tomography (OCT) enables noninvasive high-resolution 3D imaging of the human retina, and thus plays a fundamental role in ophthalmology. Via OCT examination, even subtle retinal changes can be captured, which occur in very early stages of different diseases (e.g., glaucoma, diabetes mellitus, or age-related macular degeneration). Yet, analyzing the resulting data is challenging. Conventionally, OCT data are strongly aggregated via automated methods. While this reduces the amount of information to be analyzed, it also makes it difficult, if not impossible, to identify small and localized retinal changes. This might lead to wrong diagnoses, since these methods do not account for patient-specific characteristics. We address this problem by providing new and efficient visual-interactive methods. Particularly, we introduce dedicated visualizations that show different aspects of the data. In addition, we support patient-specific selections of relevant data regions. Selected regions are emphasized, or separately visualized to inspect retinal substructures in detail. By visually comparing the regions to reference data, even very small retinal changes can be detected. We demonstrate the utility of our approach by applying it to data of a study with pediatric patients suffering from diabetes mellitus type 1. Our results show that visual-interactive methods indeed help to analyze subtle retinal changes and, thus, support the diagnosis of diseases in an early stage.

Assessing youth offenders in a non-Western context: The predictive validity of the YLS/CMI ratings.

Empirical support for the usage of the Youth Level of Service measures has been reported in studies conducted in the North America, United Kingdom, and Australia. Recent meta-analytic studies on the Youth Level of Service/Case Management Inventory (YLS/CMI) have revealed that the measure has modest to moderate predictive validity for general recidivism, but there are very few studies on the predictive validity of the YLS/CMI ratings for recidivism in non-Western contexts. This study examined the predictive validity of the YLS/CMI 2.0 ratings for general recidivism in a sample of 3,264 youth offenders within a Singaporean context (Mfollow-up = 1,764.5 days; SDfollow-up = 521.5). Results showed that the YLS/CMI 2.0 overall risk ratings and total scores significantly predicted general recidivism for both male and female youth offenders. Overall, the results suggest that the YLS/CMI 2.0 is suited for assessing youth offenders in terms of their risk for general recidivism within a non-Western context.

Synthetic corneal inlays.

This review is based on the activities of the Vision Cooperative Research Centre (previously Cooperative Research Centre for Eye Research and Technology) Corneal Implant team from 1991 to 2007. The development of a synthetic polymer of perfluoropolyether (PFPE), meeting essential physical and biological requirements, for use as a corneal inlay is presented. Each inlay was placed in a corneal flap created with a microkeratome and monitored over a two-year period in a rabbit model. The results indicate that the PFPE implant shows excellent biocompatibility and biostability. As a result, a Phase 1 clinical trial is being conducted. Three years post-implantation, the PFPE inlays are exhibiting continued excellent biocompatibility. Corneal inlays made from PFPE are biocompatible with corneal tissue in the long term and offer a safe and biologically-acceptable alternative to other forms of refractive surgery.